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Immediately following bolus administration of 20 mg 0. The infusion may be maintained for up to 24 hours. Diltiazem shows dose-dependent, non-linear pharmacokinetics. Use within 24 hours. Keep refrigerated until use. Diltiazem hydrochloride injection was tested for compatibility with three commonly used intravenous fluids at a maximal concentration of 1 mg diltiazem hydrochloride per milliliter. Because of potential physical incompatibilities, it is recommended that diltiazem hydrochloride not be mixed with any other drugs in the same container.
If possible, it is recommended that diltiazem hydrochloride not be coinfused in the same intravenous line. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Physical incompatibilities precipitate formation or cloudiness were observed when diltiazem hydrochloride was infused in the same intravenous line with the following drugs: Transition to Further Antiarrhythmic Therapy: Transition to other antiarrhythmic agents following administration of diltiazem hydrochloride injection is generally safe.
In controlled clinical trials, therapy with antiarrhythmic agents to maintain reduced heart rate in atrial fibrillation or atrial flutter or for prophylaxis of PSVT was generally started within 3 hours after bolus administration of diltiazem. These antiarrhythmic agents were intravenous or oral digoxin, Class 1 antiarrhythmics e. Experience in the use of antiarrhythmic agents following maintenance infusion of diltiazem hydrochloride injection is limited.
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To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Moderate diazepam food Applies to: Therapeutic duplication warnings No therapeutic duplications were found for your selected drugs. Drug Interaction Classification The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant. Unknown No information available. How to Prevent Deadly Drug Interactions. Some mixtures of medications can lead to serious and even fatal consequences. Ilumya Ilumya tildrakizumab-asmn is a humanized, anti-ILp19 monoclonal antibody for the treatment of Cimduo Cimduo lamivudine and tenofovir disoproxil fumarate is a combination of two nucleo t side reverse ZTlido ZTlido lidocaine topical system 1.