If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Valium is available as follows: Amnestic effects may be associated with inappropriate behavior. Flumazenil, a specific benzodiazepine-receptor antagonist , is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Your condition will not improve any faster, and your risk of side effects will increase. Store in dry place at room temperature.
Prescribed: Diazepam 10 mg tablets tevar
|Diazepam 10 mg tablets tevar||333|
|DRUG DIAZEPAM MEDICATION||What is diazepam 2mg tablets|
|Diazepam information peak time immemorial meaning||32|
|Diazepam schedule 2018 nba||Diazepam 5mg suppository how to insert a check|
|Diazepam dosage forms slideshare powerpoint||938|
Reduces emotional effects, autonomic and motor stimuli that disturb sleep. Anticonvulsant action is realized by increasing presynaptic inhibition suppresses the spread of seizure pulse, but does not eliminate the excited state of the hearth. Central muscle relaxant effect is due to inhibition of polysynaptic spinal afferent inhibitory ways to a lesser extent - and monosynaptic. Perhaps, and direct inhibition of motor nerve and muscle function.
Hypersensitivity including to other benzodiazepines , coma, shock, myasthenia gravis, angle-closure glaucoma acute onset or predisposition , acute alcohol poisoning with the weakening of vital functions , narcotic analgesics and sleeping drugs, severe COPD possibly increasing respiratory failure , acute respiratory failure, severe depression suicidal tendencies may emerge ; pregnancy especially the I trimester , lactation, age 18 years safety and effectiveness are not determined.
Symptomatic therapy maintenance of respiration and blood pressure , administration of flumazenil in the hospital. Hemodialysis - is ineffective. For the treatment of nevpoticheskih, psychopathic, and psihopatopodobnyh initial dose - 0. After days in view of efficacy and tolerability, the dose can be increased to 6. The average daily dose - 1. In neurological practice for diseases with muscle hypertonicity appoint mg times a day. In order to avoid the development of drug dependence at course treatment duration Phenazepam application is 2 weeks in some cases the duration of treatment can be increased up to 2 months.
If you cancel Phenazepam reduce the dose gradually. Important notice - the outer box design may vary before prior notice! Frequent search requests on our site: Doctor Doping Shop DR. Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol have occurred following abrupt discontinuance of diazepam. These withdrawal symptoms may consist of tremor, abdominal and muscle cramps, vomiting, sweating, headache, muscle pain, extreme anxiety, tension, restlessness, confusion and irritability.
In severe cases, the following symptoms may occur: The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms e. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed.
Chronic use even at therapeutic doses may lead to the development of physical dependence: A transient syndrome whereby the symptoms that led to treatment with Valium recur in an enhanced form. This may occur upon discontinuation of treatment. It may be accompanied by other reactions including mood changes, anxiety, and restlessness. Since the risk of withdrawal phenomena and rebound phenomena is greater after abrupt discontinuation of treatment, it is recommended that the dosage be decreased gradually.
However, there is no effect on the extent of absorption. The lower peak concentrations appear due to a slower rate of absorption, with the time required to achieve peak concentrations on average 20 - 25 minutes greater in the presence of antacids. However, this difference was not statistically significant.
There is a potentially relevant interaction between diazepam and compounds which inhibit certain hepatic enzymes particularly cytochrome P 3A and 2C Data indicate that these compounds influence the pharmacokinetics of diazepam and may lead to increased and prolonged sedation. At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole. There have also been reports that the metabolic elimination of phenytoin is decreased by diazepam.
Valium is not recommended in the treatment of psychotic patients and should not be employed instead of appropriate treatment. Since Valium has a central nervous system depressant effect, patients should be advised against the simultaneous ingestion of alcohol and other CNSdepressant drugs during Valium therapy. An increased risk of congenital malformations and other developmental abnormalities associated with the use of benzodiazepine drugs during pregnancy has been suggested.
There may also be non- teratogenic risks associated with the use of benzodiazepines during pregnancy. There have been reports of neonatal flaccidity, respiratory and feeding difficulties, and hypothermia in children born to mothers who have been receiving benzodiazepines late in pregnancy. In addition, children born to mothers receiving benzodiazepines on a regular basis late in pregnancy may be at some risk of experiencing withdrawal symptoms during the postnatal period.
Cleft palate and encephalopathy are the most common and consistently reported malformations produced in these species by administration of high, maternally toxic doses of diazepam during organogenesis. Rodent studies have indicated that prenatal exposure to diazepam doses similar to those used clinically can produce long-term changes in cellular immune responses, brain neurochemistry, and behavior.
In general, the use of diazepam in women of childbearing potential, and more specifically during known pregnancy, should be considered only when the clinical situation warrants the risk to the fetus. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Patients should also be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physician about the desirability of discontinuing the drug. Special care must be taken when Valium is used during labor and delivery, as high single doses may produce irregularities in the fetal heart rate and hypotonia , poor sucking, hypothermia, and moderate respiratory depression in the neonates.
With newborn infants it must be remembered that the enzyme system involved in the breakdown of the drug is not yet fully developed especially in premature infants. Diazepam passes into breast milk. Breastfeeding is therefore not recommended in patients receiving Valium. The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression or anxiety associated with depression, particularly the recognition that suicidal tendencies may be present and protective measures may be necessary.
Should this occur, use of the drug should be discontinued. These reactions are more likely to occur in children and the elderly. A lower dose is recommended for patients with chronic respiratory insufficiency , due to the risk of respiratory depression. Benzodiazepines should be used with extreme caution in patients with a history of alcohol or drug abuse see Drug Abuse And Dependence.
In debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation 2 mg to 2. Some loss of response to the effects of benzodiazepines may develop after repeated use of Valium for a prolonged time. The data currently available are inadequate to determine the mutagenic potential of diazepam. Safety and effectiveness in pediatric patients below the age of 6 months have not been established.
In elderly patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation 2 mg to 2. Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects. Metabolites of this drug are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function.
Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Decreases in clearance and protein binding, and increases in volume of distribution and half-life have been reported in patients with cirrhosis. In such patients, a 2- to 5- fold increase in mean half-life has been reported. Delayed elimination has also been reported for the active metabolite desmethyldiazepam.
Benzodiazepines are commonly implicated in hepatic encephalopathy. Pharmacokinetics in Special Populations: Overdose of benzodiazepines is usually manifested by central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, confusion, and lethargy. In more serious cases, symptoms may include ataxia , diminished reflexes, hypotonia , hypotension , respiratory depression, coma rarely , and death very rarely.
Overdose of benzodiazepines in combination with other CNS depressants including alcohol may be fatal and should be closely monitored. Following overdose with oral benzodiazepines, general supportive measures should be employed including the monitoring of respiration , pulse , and blood pressure. Vomiting should be induced within 1 hour if the patient is conscious. Gastric lavage should be undertaken with the airway protected if the patient is unconscious. Intravenous fluids should be administered.
If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption. Special attention should be paid to respiratory and cardiac function in intensive care. General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Should hypotension develop, treatment may include intravenous fluid therapy, repositioning, judicious use of vasopressors appropriate to the clinical situation, if indicated, and other appropriate countermeasures.
Dialysis is of limited value. As with the management of intentional overdosage with any drug, it should be considered that multiple agents may have been ingested. Flumazenil, a specific benzodiazepine-receptor antagonist , is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access.
Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose.
Caution should be observed in the use of flumazenil in epileptic patients treated with benzodiazepines. Withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines see Drug Abuse And Dependence. Valium is contraindicated in patients with a known hypersensitivity to diazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age.
Valium is also contraindicated in patients with myasthenia gravis , severe respiratory insufficiency, severe hepatic insufficiency, and sleep apnea syndrome. It may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow-angle glaucoma.
Diazepam is a benzodiazepine that exerts anxiolytic, sedative , musclerelaxant, anticonvulsant and amnestic effects.What Colour Are Diazepam Tablets?