Dose Recommended dose is 0. When administered intravenously transient, high serum and brain concentrations of diazepam are achieved with 1 minute. Benzodiazepines diazepam, lorazepam, midazolam, and clonazepam are potent, fast-acting anticonvulsants and therefore particularly diazepam , are the preferred initial therapy in status epilepticus SE. With its relatively brief duration of action however, diazepam is not a definitive therapy for SE. There was blood all over the car seat. If you are unsure of the pet's liver status, use phenobarbital and diazepam carefully. J Vet Pharmacol Therap 21 ,
A rubber catheter or teat cannula is then placed on the syringe to facilitate rectal administration. Suppository forms of diazepam are available, but the pharmacokinetics of these products in dogs has not been evaluated. Additional doses of maintenance oral antiepileptic drugs, or pulse therapy with one of the newer drugs in which a medication is administered only during the cluster event , have also been advocated to treat repeated seizures at home, but no published reports have documented the efficacy of such treatments.
The use of diazepam per rectum at home for the acute management of cluster seizures in dogs. J Vet Intern Med ;9 2: Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog. J Vet Pharmacol Ther ;21 5: Anesthesia Atopic dermatitis Canine cranial cruciate ligament injuries Canine and feline lymphoma Canine house training Canine hyperadrenocorticism Canine influenza Chronic and acute renal disease Cognitive dysfunction Congestive heart failure Diabetes mellitus Feline hyperthyroidism Feline inappropriate elimination Fleas Food allergy Gastric dilatation-volvulus Geriatric medicine Glaucoma Heartworm disease Leptospirosis Low-stress techniques Nutrition nuggets Obesity in pets Osteoarthritis Otitis Pancreatitis and gastrointestinal disease Periodontal disease Separation anxiety Ticks Urinary tract disease Wound management and skin grafts.
All dermatology Ear disease. All exotic-animal medicine Avian medicine. Continuous use in prolonged seizures should be avoided as a diminished response is seen with repeated administration. Intravenous administration of diazepam may not be possible in some patients. It can be administered intramuscularly IM , although absorption is not predictable. Rectal administration of diazepam may be considered initially at a dose of 0. It may be necessary to use the higher dose in dogs receiving long-term phenobarbital therapy.
Adverse effects of intravenous benzodiazepines include respiratory depression, hypotension, and impaired consciousness. Platt S, Randell SC, Scott KC et al Comparison of plasma benzodiazepine concentrations following intranasal and intravenous administration of diazepam in dogs. AJVR 61 , Podell M The use of diazepam per rectum at home for the acute management of cluster seizures in dogs. Wagner SO, Sams RA, Podell M Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog.
J Vet Pharmacol Therap 21 , Induction to the scheme.